Correlation of serum levels of IgA anti-tissue transglutaminase (IgA tTG) with the histological severity in celiac disease

The Diagnostic Value of Serum IgG-Antigliadin, IgA Anti-endomysial and IgA Anti-tissue Transglutaminase Antibodies for Pediatric Celiac Disease

  Background and Objective: Celiac disease is an autoimmune disorder, characterized by inflammation, villous atrophy, and crypt hyperplasia of the small bowel mucosa. In this study we considered and compared sensitivity and specificity of serological tests in patients with celiac disease. Materials and Methods: In this cross-sectional study we prospectively recruited children with suspected c...

The Utility of Anti-tissue Transglutaminase Antibody-IgA (tTG-IgA) Testing for Celiac Disease in Adults with Down Syndrome

Results: Of these patients, 141 (92.8%) had a positive tTG-IgA and 11 (7.2%) had a negative result. Eighty-one (53.3%) did not have an EGD performed due to patient or legal representatives declining. Of the 71 who had a biopsy, the result of the tTG-IgA in 29 (40.8%) was a true positive, 35 (49.3%) a false positive, 2 (2.8%) a true negative, and 5 (7.0%) a false negative. The sensitivity was 85...

the diagnostic value of serum igg-antigliadin, iga anti-endomysial and iga anti-tissue transglutaminase antibodies for pediatric celiac disease

background and objective: celiac disease is an autoimmune disorder, characterized by inflammation, villous atrophy, and crypt hyperplasia of the small bowel mucosa. in this study we considered and compared sensitivity and specificity of serological tests in patients with celiac disease. materials and methods: in this cross-sectional study we prospectively recruited children with suspected celia...

Correlation between IgA tissue transglutaminase antibody ratio and histological finding in celiac disease.

OBJECTIVES Positivity of both immunoglobulin A anti-tissue transglutaminase (TTG) and anti-endomysium antibodies (EMA) has a positive predictive value of nearly 100% for celiac disease (CD). The objective of the present study was to evaluate whether patients of any age, with high pretest probability of CD and high titre of anti-TTG and EMA positivity, have a high probability of intestinal damag...

Utility in Clinical Practice of Iga Anti-tissue Transglutaminase Antibody for the Diagnosis of Celiac Disease